Difluoromethyl compounds, denoted by the chemical formula CF2H, are organic molecules that include the difluoromethyl group. Two fluorine atoms bound to a single carbon atom that is also linked to a hydrogen atom make up this group. Organic molecules that have difluoromethyl groups added to them frequently acquire special and advantageous qualities that make them useful in a variety of industries, including materials science, agrochemicals, and pharmaceuticals. Difluoromethylating reagents are a popular tool used in the synthesis of difluoromethyl compounds. Usually connected to another atom or functional group, these chemicals have a difluoromethyl group that makes it easier for the target molecule to incorporate them. Difluoromethyl iodide (CF2HI), difluoromethyl phenyl sulfide (CF2HSC6H5), and difluoromethyl p-tolyl sulfone (CF2HSO2C6H4CH3) are a few examples of difluoromethylating reagents. It is well known that difluoromethyl groups can alter the physicochemical characteristics of organic molecules. Difluoromethyl groups can be added to drug candidates in medicinal chemistry to improve their lipophilicity, metabolic stability, and overall pharmacokinetic profile. As a result, medications containing difluoromethyl have been developed with better therapeutic efficacy and bioavailability. Difluoromethyl compounds are used as crop protection agents in agrochemistry. Difluoromethyl groups in pesticides can increase their biological activity, which improves their ability to manage agricultural pests and illnesses. Difluoromethyl groups aid in the creation of sophisticated materials with particular electrical and optical characteristics in the field of materials science. To obtain desirable performance characteristics, researchers investigate the insertion of difluoromethyl moieties into liquid crystals, polymers, and other materials. Difluoromethyl compounds have several advantages, but synthesising them and incorporating them into complicated molecules can be difficult. Nonetheless, in order to ensure that difluoromethylated chemicals continue to be important for a variety of scientific and industrial uses, continuous research efforts are concentrated on creating effective and sustainable techniques for their synthesis.
